DOSING

DOSING

Twice-yearly dosing schedule for patients

  • After two initial doses, Uplizna™ (inebilizumab-cdon) only needs to be administered twice a year, in 90-minute infusions¹
  • 300-mg intravenous (IV) infusion for approximately 90 minutes: initial dosing at Day 1 and Day 15, and then every six months for maintenance¹

300 mg IV infusion over approximately
90 minutes twice per year after initial dosing

Day 1
Day 15
Every 6 months
for maintenance

Managing potential infusion reactions

  • Administer premedication with corticosteroid, antihistamine and antipyretic approximately 30 minutes prior to each Uplizna infusion¹

Premedication: administer approximately 30-60 minutes prior to each Uplizna infusion

Type of premedication Route of administration Examples of
(or equivalent)
Administration
time prior to Uplizna infusion
corticosteroid intravenous methylprednisolone
80 mg to 125 mg
30 minutes
antihistamine oral diphenhydramine
25 mg to 50 mg
30 to 60 minutes
antipyretic oral acetaminophen
500 mg to 650 mg
30 to 60 minutes
Type of premedication
corticosteroid
Route of administration
intravenous
Examples of (or equivalent)
methylprednisolone
80 mg to 125 mg
Administration time
prior to Uplizna infusion

30 minutes
Type of premedication
antihistamine
Route of administration
oral
Examples of (or equivalent)
diphenhydramine
25 mg to 50 mg
Administration time
prior to Uplizna infusion

30 to 60 minutes
Type of premedication
antipyretic
Route of administration
oral
Examples of (or equivalent)
acetaminophen
500 mg to 650 mg
Administration time
prior to Uplizna infusion

30 to 60 minutes

Get more information on the distribution of Uplizna, including distributor contact phone numbers:

Uplizna Product Fact Sheet

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Access and Support

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Patient resources

Resources for Your Patients

Conversation guides and downloadable materials to help inform and educate your patients about Uplizna.

See patient resources

Reference: 1. Uplizna [prescribing information]. Gaithersburg, MD: Viela Bio; June 2020.